SPDB-DM4

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SPDB-DM4
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Linker-Toxin SET, Linker-Toxin SET, This set is made by DM4 conjugated to SPDB linker. DM4 belongs to Maytansinoids which are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells. SPDB, a disulfide linker, is extensively exploited as a chemically labile linkage. https://www.creative-biolabs.com/adc/classify-drug-linker-complexes-8.htm
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