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Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1.Bufalin could partly reverse the MDR of K562/VCR cells, with a possible mechanism of down-regulating MRP1 expression and activating apoptosis pathway by altering Bcl-xL/Bax ratio.
www.bocsci.com/bufalin-cas-465-21-4-item-5-464396.html

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Alex Brown