Summary: Creative biolabs has adopted and perfected several techniques to study antibody/ADC internalization for the selection of suitable antibodies for ADC development and for the validation of the internalization of the corresponding ADCs. Our approaches include radiolabels, fluorescent microscopy, flow cytometry…, among which antibody/ADC fluorescence labeling is the most common. Various organic dyes, especially some pH-sensitive dyes have been used in this application and the resulted antibody/ADC internalization is characterized using fluorescent or confocal microscopy. For more information regarding “internalizing” antibody selection, please visit our “Internalizing antibody screening” webpage. Creative Biolabs provides multi-approach internalization analysis services to help select internalizing antibodies and verify the internalization of an ADC. https://www.creative-biolabs.com/adc/adc-internalization-assay.htm
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